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Мой Геном » Новости генетики » От сердечников до шизофреников — один ген

От сердечников до шизофреников — один ген

Дата: 2009-05-31 / Обсуждение [76]

Шизофрения считается одной из самых загадочных болезней. До сих пор непонятно, что именно ее вызывает. По одной из версий, это психическое расстройство связано с генетикой. Очередное подтверждение этому нашли американские ученые. Они установили, что в мозге шизофреников активен один из вариантов гена KCNH2. Он связан с работой калиевых каналов, которые влияют на скорость передачи сигналов между нейронами.

С мутацией гена KCNH2 связывают и некоторые сердечные заболевания, например синдром короткого интервала QT, при котором возможна внезапная остановка сердца. Теперь становится понятно, почему некоторые лекарства от шизофрении оказывают побочный эффект на сердечную деятельность.

Источник: Stephen Huffake, Jingshan Chen et al. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia // Nature medicine, 2009. № 15. Pp. 509–518.

Источник: Эксперт


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