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ћой √еном » Ќовости генетики » ќт сердечников до шизофреников Ч один ген

ќт сердечников до шизофреников Ч один ген

ƒата: 2009-05-31 / ќбсуждение [27]

Ўизофрени€ считаетс€ одной из самых загадочных болезней. ƒо сих пор непон€тно, что именно ее вызывает. ѕо одной из версий, это психическое расстройство св€зано с генетикой. ќчередное подтверждение этому нашли американские ученые. ќни установили, что в мозге шизофреников активен один из вариантов гена KCNH2. ќн св€зан с работой калиевых каналов, которые вли€ют на скорость передачи сигналов между нейронами.

— мутацией гена KCNH2 св€зывают и некоторые сердечные заболевани€, например синдром короткого интервала QT, при котором возможна внезапна€ остановка сердца. “еперь становитс€ пон€тно, почему некоторые лекарства от шизофрении оказывают побочный эффект на сердечную де€тельность.

»сточник: Stephen Huffake, Jingshan Chen et al. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia // Nature medicine, 2009. є 15. Pp. 509Ц518.



»сточник: Ёксперт




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